Cam across this interesting article from Jeffery Loo at University of California Berkeley demonstrating how they created several videos about using PubChem. They used Powerpoint for the slides, GIMP to edit graphics, Audacity to recoird and edit the audio, Screen-cast-o-matic to create the screencasts, Windows Live Movie Maker to edit it, and Youtube to store and distribute.
They last about 6 minutes each. Here is a sample
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